Dr( Col) Joy Dev Mukherji, MD:DM;FRCP(Edin), Principal Director and Head department of Neurology, Max Super Specialty Hospital, Saket New Delhi
Neurological complications following COVID-19 are being reported in large numbers .Among 236 379 patients diagnosed with COVID-19, the estimated incidence of a neurological or psychiatric diagnosis in the following 6 months was 33•62% as reported by Maxime Taquet et al in Lancet Psychiatry 2021; 8: 416–27.
The neurologic manifestations of the disease can be classified into central nervous system (CNS) symptoms and peripheral nervous system (PNS) symptoms.The common neurological conditions associated with Covid-19 infection include:
Mechanism of Central Nervous System (CNS) Involvement
SARS-CoV-2 uses its spike protein (S-protein) to bind to angiotensin-converting enzyme 2 (ACE2), which the functional receptor of the virus. This results in cleavage of the S-protein. This results in attachment of the virus to the human cell membrane and subsequent  entry of the viral genome into the cell. The host cell then propagates the virus as well as mounts the immune response .